The Jameel Clinic have just released Boltz-1, an open-source model designed to accurately model complex biomolecular interactions. Boltz-1 is an open-source model which predicts the 3D structure of proteins, rna, dna and small molecules; it handles modified residues, covalent ligands and glycans, as well as condition the generation on pocket residues with AlphaFold 3 accuracy.
Details are here https://jclinic.mit.edu/boltz-1/
Code is on GitHub https://github.com/jwohlwend/boltz
Model and code are released under MIT License, and can be freely used for both academic and commercial purposes.
To install
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pip install boltz |