Apple have released the latest update to the macOS operating system Sonoma

Whilst there are many sites that describe compatibility with common applications it is often difficult to find information on scientific applications.

Which Macs are compatible?

macOS Sonoma is compatible with these computers
MacBook Pro (16-inch, 2023)
MacBook Pro (14-inch, 2023)
MacBook Pro (13-inch, M2, 2022)
MacBook Pro (16-inch, 2021)
MacBook Pro (14-inch, 2021)
MacBook Pro (13-inch, M1, 2020)
MacBook Pro (13-inch, 2020, two Thunderbolt 3 ports)

You can find out your Mac model by tapping on the Apple icon in the menu bar and going to About This Mac.

Scientific Applications
I’ve contacted all developers I know and their responses to date are shown below, first impressions are this is a relatively benign update

alvaScience all our tools support MacOS Sonoma.

Amsterdam Modeling Suite seems to run fine.

Anaconda Anaconda3 installed without problems.



AutoDock Vina The 64 bit version is expected to work on Mac OS X 10.15 (Catalina) and newer.

BBEdit The following versions of our products are provisionally recommended for use with macOS 14 “Sonoma”: BBEdit 14.6.7, Yojimbo 4.6.3. BBEdit versions prior to 14.6 will not run on macOS Sonoma.


Bruker Topspin 4.2.0 works

ChemAxon Most of our software in general requires Java, so as long as the appropriate Java version is installed, there should be no problem.

ChemDraw 22 All working as expected

ChemDoodle The latest versions of ChemDoodle 2D (v12) and ChemDoodle 3D (v7) are fully supported on macOS 14 Sonoma (released 9/26/2023) and there are no known issues.

ChimeraX Open the downloaded DMG file and drag ChimeraX to your Applications folder. Includes native versions for M2, M1 and Intel Macs. Works on macOS 10.15 and newer.

Chirys View

Conquest and Mercury from CCDC

Cresset no issues whatsoever with Flare or Spark

CrystalMaker In common with other developers, we’ve seen some minor OpenGL on Apple Silicon machines. It doesn’t affect the operation of the software and I suspect this is an Apple bug that will get fixed soon.

DataWarrior All seems to be working fine.

DeltaGraph We are currently preparing for the 64 bit version of DeltaGraph Mac. However, at this time we cannot announce our plans or a possible release date.

Elemental Fine under Sonoma and on Apple Silicon

EndNote runs on macOS 10.14, 10.15, 11, 12, 13, 14 on Apple-Silicon based Macs

EnzymeX are all working fine on Sonoma.


FileMaker Pro 2023 (20.2) is compatible with macOS Sonoma 14.0 with the following known issues:

Fujitsu ScanSnap works

GAMESS OSX 12.4-12.6 and 13.30 build support. (#828) (#845)

Gaussaian installation using Home-brew seems to be working fine.

gFortran Standalone installer of GCC 12.2, including gfortran, for macOS Ventura (macOS 13) Apple silicon and Intel

Graphpad Prism Requires update to v10.0.3

Homebrew Seems to work fine, remember to reinstall Xcode command line tools.

iBabel no issues reported

Igor Pro WaveMetrics is not working on an ARM port and have no concrete plan to do so.

ImageJ2 2.9.0 works

iNMR version 7 supports 10.11 or higher

JalView as long as the appropriate Java version is installed, there should be no problem.

KaleidaGraph v5 will run on OS 10.14 or later and supports the M1/M2 chip.

KNIME We know of two non-blocking issues that are Eclipse-related: The name of the app is incorrect and the splash screen is upside down. Apart from these two, we are not aware of anything.

Manuscripts no issues reported

MATLAB is compatible with macOS 13 (Ventura) and macOS (Sonoma) and as of R2023b, MATLAB runs natively on Apple silicon. Macs.



Microsoft Office Supported on version 16.78 or later

Mnova should work fine.

MOE Initial tests showed no issues with this version.

Molsoft ICM Now Available for macOS Sonoma


NAG Fortran compiler

nucleobytes apps are all working fine on Sonoma.

OpenBabel no issues reported

ODYSSEY ntel or M1 chip Macintosh (only), 2GHz chip or faster OS 10.12 (Sierra) through OS 13.X (Ventura) 128 GB disk space or higher (SSD Recommended) 4 GB RAM or higher

Orca Orca 5.0.3 runs on Apple Silicon

Parallels 19 is compatible with macOS Samona

pro Fit pro Fit 7.1 requires Mac OS 12 (Monterey) or later.

PYMOL Seems to run fine

Python Python 2.7 is no longer included – use Python 3 instead. Python works fine on Apple Silicon and is “mad fast!”.

QMForge 2.4

R Package R-4.x.x-arm64.pkg is a ‘native’ build for ‘Apple Silicon’

RDKit All seems fine (Note: -Python 2.7 is no longer supported – use Python 3 instead)

Samson We have used SAMSON on Sonoma and haven’t observed any issues related to the OS update.

Schrodinger macOS Sonoma is the latest release of Apple’s operating system and we have started testing the Schrodinger suite. We plan to support macOS 14 (Sonoma) for our next release 23-4.

SeeSAR SeeSAR & infiniSee No incompatibilities were observed with macOS 10.14 (Mojave) and higher.

Simply Fortran Fortran development environment for macOS 12 or higher on Intel, early build for Apple Silicon. Mac OS 13

Sketch Version 96.3 supports Somona

Snapgene viewer v7.0 works

Spartan Intel or Mx chip 4 GB RAM or higher no issues with Sonoma 128 GB disk space or higher (SSD Recommended)

SPSS Apple released macOS 14.0 (Sonoma) on September 26th, 2023. The SPSS Statistics Development team is actively testing this release of macOS with our IBM SPSS Statistics products. Adding macOS 14.0 (Sonoma) as one of our supported platforms is a high priority item and an IF is estimated to be delivered on Friday, October 13th, 2023.

Stardrop No reported issues

Swiss-PdbViewer is a 32 bits application and will * NOT * run.

TensorFlow and TensorFlow Addons


Vortex Vortex works perfectly on Apple Silicon Macs under Sonoma and is blazingly fast.



Xcode need to update to latest version Xcode 15. Remember to reinstall command line tools

XQuartz OpenGL and OpenCL are still here and function as expected, you may need to reinstall XQuartz

Zoom works

Zotero 6.0.26 and Zotero 7 beta work

I’ll add more updates later, feel free to contact me and thanks for the comments to date.

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