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Hints and Tutorials Macinchem Blog

RDMA over Thunderbolt support is now in macOS 26.2

19 December 202519 December 2025 chris

Remote direct memory access (RDMA) is direct memory access from the memory of one computer into that of another without involving either computer’s operating system. This permits high-throughput, low-latency memory access over

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Data Analysis Tools Hints and Tutorials Macinchem Blog Vortex Scripts

Vortex script for Hit expansion

9 December 20259 December 2025 chris

One of the frequent situations after running a screen is you have a list of hits and you want to select related analogues to explore

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Hints and Tutorials Macinchem Blog

External drives for Mac

30 November 202530 November 2025 chris

I’ve updated the page describing my testing of various external hard drive options. https://macinchem.org/wp-admin/post.php?post=1899 On my Mac Studio M2 Ultra the ACASIS 80Gbps M.2 NVMe

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Hints and Tutorials Macinchem Blog

External SSD drives

21 November 202521 November 2025 chris

I’ve just purchased another external hard drive, after reviewing options I ended up buying another Acacias enclosure with the Crucial P310 4TB SSD M.2 2280

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Data Analysis Tools Hints and Tutorials Macinchem Blog Science Apps

TabPFN-2.5

10 November 202510 November 2025 chris

I’ve reviewed TabPFN in the past. https://macinchem.org/2025/02/06/looking-at-tabpfn and I noticed there was a recent update. TabPFN is a foundation model  trained on around 130,000,000 synthetically generated

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Hints and Tutorials Macinchem Blog

Use the Foundation Models framework to access the on-device LLM that powers Apple Intelligence.

8 October 2025 chris
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Hints and Tutorials Macinchem Blog

MayaChemTools updated

2 October 20252 October 2025 chris

The excellent MayChemTools has been updated MayaChemTools is a growing collection of Perl and Python scripts, modules, and classes to support a variety of day-to-day computational discovery needs. The

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Data Analysis Tools Hints and Tutorials Macinchem Blog

ChEMBL 36 is out

26 September 202526 September 2025 chris

One of the most useful databases for anyone involved in studies involved in biologically active molecules. ChEMBL is a manually curated database of bioactive molecules

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Hints and Tutorials Jupyter Notebook Macinchem Blog

SimpleFold: Folding Proteins is Simpler than You Think

24 September 202524 September 2025 chris

Apple just posted preprint on arxiv describing a new protein structure prediction tool SimpleFold https://arxiv.org/pdf/2509.18480. All code is available on GitHub https://github.com/apple/ml-simplefold including a simple

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Hints and Tutorials Macinchem Blog

XQuartz and macOS Tahoe

18 September 202519 September 2025 chris

A couple of readers have mentioned issues with using XQuartz after upgrading to macOS Tahoe. Looking on GitHub there are a couple issues. https://github.com/XQuartz/XQuartz/issues/446 https://github.com/XQuartz/XQuartz/issues/438

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  • RSC Analyticode
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  • Vortex script for Hit expansion
  • External drives for Mac
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