There are a number of chemical drawing packages around that range from lightweight apps for providing structure input to database searches to large fully features packages designed to provide publication quality images. A number of these packages have not been updated recently and so it is great to see another choice available.
AlvaSketcher is a modern molecular editor for drawing, editing, and preparing 2D chemical structures. It is available for macOS and runs on both Apple Silicon and Intel Macs.
It has a modern interface with all the usual chemical drawing tools readily to hand. AlvaSketcher is freely available both for academic research and commercial applications.
There is also a short (1 min) tutorial on YouTube which shows how intuitive it is to use. Skecthes can be saved in SMILES or sdf format. You can also copy as SMILES (and sdf or image) which is very useful for pasting into other cheminformatics tools. I tried to open a few different file formats, and in addition to SMILES and sdf, it opened .mol and .mol2 files. This is intended as a 2D sketcher so files containing 3D structures don’t display ideally. For files containing multiple structures the first structure is loaded.