Cryo-EM structures are sometimes modest resolution which can be an issue for small molecule docking. ChemEM is a software package for docking small molecules into medium-to-high-resolution cryo-EM structures DOI
ChemEM is currently distributed via anaconda.
conda install -c chemem -c conda-forge chemem
pip install BioTEMPy==2.0.0
Full details are in the Quickstart guide