Installing local LLM on Apple Silicon

11 December 202311 December 2023 chris

Great video by Alex Ziskind on installing a local large language models on Apple Silicon.

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@macinchem.bsky.social 3 days

AlvaSketcher

There a number of chemical drawing packages around that range from lightweight apps for providing structure input to database searches to large fully features packages designed to provide publication...
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@macinchem.bsky.social 1 week

dock-postprocess

This looks very useful. dock-postprocess is an open-source structure-based drug design toolkit for standardizing docking results and carrying them through restrained OpenMM minimization, pose QC, protein-ligand...

https://macinchem.org/2026/09/07/dock-postprocess/
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@macinchem.bsky.social 3 weeks

Updated Mac mini and Mac Studio

Apple have announced new Mac mini and Mac Studio machines. Mac mini has either M5 Pro chip or M6 chip M5 Pro 15‑core CPU with 5 super cores and 10 performance...

https://macinchem.org/2026/08/26/updated-mac-mini-and-mac-studio/
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@macinchem.bsky.social 3 weeks

Installing the OpenADMET PXR anvil prediction

I had a couple of issues installing the PXR model from OpenAMET on my Apple Silicon Mac (https://huggingface.co/openadmet/pxr-chemeleon-baseline) so I thought I'd...

https://macinchem.org/2026/08/25/installing-the-openadmet-pxr-anvil-prediction/
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@macinchem.bsky.social 3 weeks

mlxmolkit updated

mlxmolkit is a GPU-accelerated molecular toolkit on Apple Silicon, it is a port of nvMolKit that uses Cuda. There are now three pipelines Molecular Clustering — Morgan FP → Tanimoto...

https://macinchem.org/2026/08/25/mlxmolkit-updated/

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Installing local LLM on Apple Silicon

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