The latest update of the ChEMBL database is out. There are now nearly 3 million structures, 2 million assays covering over 18,000 targets. One of the big updates has been the targeted protein degradation.
2,921,148 compounds (of which 2,897,819 have mol files)
3,824,604 compound records (non-unique compounds)
24,527,044 activities
1,970,438 assays
18,552 targets
101,100 documents
Full details can be found here https://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_37/chembl_37_release_notes.txt
and the latest downloads are here
https://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/latest