A recent paper described Boltz-1: Democratizing Biomolecular Interaction Modeling https://www.biorxiv.org/content/10.1101/2024.11.19.624167v2
Boltz-1, an open-source deep learning model incorporating innovations in model architecture, speed optimization, and data processing achieving AlphaFold3-level accuracy in predicting the 3D structures of biomolecular complexes. Boltz-1 demonstrates a performance on-par with state-of-the-art commercial models on a range of diverse benchmarks, setting a new benchmark for commercially accessible tools in structural biology.
I tried installing Boltz-1 on Apple Silicon and whilst I did get it running the it was far from straight-forward. Fortunately, the current version of ChimeraX 1.10 will install Boltz-1 on a Mac.
Making Boltz Structure Predictions in ChimeraX https://www.rbvi.ucsf.edu/chimerax/data/boltz-apr2025/boltz_help.html A ChimeraX graphical user interface (menu Tools / Structure Prediction / Boltz) and ChimeraX command (boltz) are provided to make predictions. There is also a YouTube video showing how to make predictions.
Boltz-2 adds a few more complications and these seem to have been addressed in a pull request, but not yet merged. https://github.com/jwohlwend/boltz/pull/231 and https://github.com/fnachon/boltz