The ICM-Pro + VLS software has undergone significant updates and improvements in its built-in functionalities for modeling, docking, GUI, and visualization. These enhancements include pre-built models in MolScreen for quickly predicting the target properties and activities of compounds. Notable new features encompass advanced MD functionalities, new AI models and AI layers for property and target prediction, extended cheminformatics functions, an improved 3D ligand editor, and direct access to AlphaFold models, as reviewed below. Additionally, new modules have been developed for specialized GPU hardware. These modules are licensed separately from ICM-Pro and can be operated independently or launched via ICM-Pro + VLS. The release notes are here https://www.molsoft.com/new-features.html