One of the most useful databases for anyone involved in studies involved in biologically active molecules.
ChEMBL is a manually curated database of bioactive molecules with drug-like properties. It brings together chemical, bioactivity and genomic data to aid the translation of genomic information into effective new drugs.
Nearly 3 million molecules with over 24 million associated bio activities.
Full details of the update are available on the ChEMBL blog https://chembl.blogspot.com/2025/09/chembl-36-is-out.html
It can be downloaded here https://chembl.gitbook.io/chembl-interface-documentation/downloads