Description This Security Alert addresses security issues CVE-2012-4681 (US-CERT Alert TA12-240A and Vulnerability Note VU#636312) and two other vulnerabilities affecting Java running in web browsers on desktops. These vulnerabilities are not applicable to Java running on servers or standalone Java desktop applications. They also do not affect Oracle server-based software. These vulnerabilities may be remotely exploitable without authentication, i.e., they may be exploited over a network without the need for a username and password. To be successfully exploited, an unsuspecting user running an affected release in a browser will need to visit a malicious web page that leverages this vulnerability. Successful exploits can impact the availability, integrity, and confidentiality of the user's system. In addition, this Security Alert includes a security-in-depth fix in the AWT subcomponent of the Java Runtime Environment. Due to the severity of these vulnerabilities, the public disclosure of technical details and the reported exploitation of CVE-2012-4681 "in the wild," Oracle strongly recommends that customers apply the updates provided by this Security Alert as soon as possible.
Download for the update is here
SMARTCyp 2.2 has been released including the following updates: One new energy rule for sulfur atoms double bonded to sp2 carbon atoms. Update protonated amine SMARTS matching due to analysis of larger 2D6 data set. Faster predictions by rewriting the SMARTS matching code for the pharmacophores in the 2D6 and 2C9 models. Web site update with links to the 2C9 model paper, and prediction accuracy results on nine different isoforms. http://www.farma.ku.dk/smartcyp/
SMARTCyp has been updated to version 2.1.1. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450 a major contributor to oxidative metabolism.
The latest update now includes models for prediction of CYP2D6 and CYP2C9 specific metabolism
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